A Next Generation Tri-Complex KRASG12C(ON) Inhibitor Directly Targets the Active, GTP-Bound State of Mutant RAS and may Overcome Resistance to KRASG12C(OFF) Inhibition

R.J. Nichols, J. Cregg, C.J. Schulze, Z. Wang, K. Yang, J. Jiang, D.M. Whalen, R. Hansen, L.S. Garrenton, A. Bermingham, J.E. Knox, T. Choy, D. Reyes, M. Rios, K. Seamon, M. Longhi, K. Chou, S. Li, D.P. Wildes, M. Singh, E.S. Koltun, A. L. Gill, J.A.M. Smith