Discovery of RMC-5552, a selective bi-steric inhibitor of mTORC1 that suppresses 4EBP1 phosphorylation, for the treatment of mTORC1-activated tumors including RAS pathway escape

G.L. Burnett, J. Pitzen, M. Gliedt, C. M. Semko, J. Jiang, Y.C. Yang, C.J. Schulze, A. Marquez, J.W. Evans, S.L. Wilson, T. Hsieh, Z.C. Wang, B.J. Lee, T. Choy, D.F. Reyes, Y. Zhao, J.Y. Tao, H. Du, T. Ozawa, Q. Fan, K. Luo, G. Kiss, D.P. Wildes, D. Raleigh, Z.P. Wang, S.P. Monga, D.J. Kwiatkowski, W.A. Weiss, J. Aggen, M. Singh, J.A.M. Smith, A. Gill