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4EBP3 mRNA as a Biomarker of Therapeutic Response to Treatment with mTORC1 Inhibitors

October 28, 2019

Bianca J. Lee, Nuntana Dinglasan, Tram Nguyen, Edward G. Lorenzana, Stacy L. Wilson, G. Leslie Burnett, James B. Aggen, Robert J. Nichols, Mallika Singh, David Wildes, and Jaqueline A.M. Smith

 

AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA; Poster B108

 

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Latest Scientific Presentations

Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
Enhancement of anti-tumor immunity in immunogenic and immune-refractory RAS mutant tumors with tri-complex RAS(ON) inhibitors
The Bi-steric mTORC1-Selective Inhibitor RMC-5552 in Tumors with Activation of mTOR Signaling: Preclinical Activity in Combination with RAS(ON) Inhibitors in RAS-Addicted Tumors, and Initial Clinical Findings from A Single Agent Phase 1/1b Study
RMC-6291, a Next-Generation Tri-Complex KRAS-G12C(ON) Inhibitor, Outperforms KRAS-G12C(OFF) Inhibitors in Preclinical Models of KRAS-G12C Cancers
Translating Frontier Oncology Targets to Outsmart RAS-Addicted Cancers
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