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4EBP1 Reactivation by Potent and Selective Bi-steric Inhibitors of mTORC1

December 1, 2018

Abby Marquez, Arun Thottumkara, Zhengping Wang, Stacy Wilson, Frances Zhao, Mark A. Goldsmith, Mallika Singh, David Wildes, Adrian L. Gill, and Jacqueline A. M. Smith

 

AACR Targeting PI3K/mTOR Signaling; November 30 to December 3, 2019; Boston, MA.

 

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Latest Scientific Presentations

Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors
Enhancement of anti-tumor immunity in immunogenic and immune-refractory RAS mutant tumors with tri-complex RAS(ON) inhibitors
The Bi-steric mTORC1-Selective Inhibitor RMC-5552 in Tumors with Activation of mTOR Signaling: Preclinical Activity in Combination with RAS(ON) Inhibitors in RAS-Addicted Tumors, and Initial Clinical Findings from A Single Agent Phase 1/1b Study
RMC-6291, a Next-Generation Tri-Complex KRAS-G12C(ON) Inhibitor, Outperforms KRAS-G12C(OFF) Inhibitors in Preclinical Models of KRAS-G12C Cancers
Translating Frontier Oncology Targets to Outsmart RAS-Addicted Cancers
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