Scientist I/II, Lead Discovery

REVOLUTION Medicines, a clinical stage biotech company, dedicated to discovering and developing new drugs that translate frontier cancer targets through exceptional drug discovery delivering revolutionary medicines on behalf of cancer patients.  Our innovative science draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches.  As a new member of the RevMed team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.


As a key player in our Lead Discovery group, you will:

  • Work with the Target Discovery Biology and Discovery Technologies departments to assess and characterize new Frontier Oncology targets for lead discovery potential.

  • Develop, enable and execute biochemical and biophysical assays and other experiments to characterize proteins and assess ligand/protein interactions in service of discovery project teams.

  • Collaborate with chemists, biochemists, structural biologists and pharmacologists to generate novel insights that fuel drug development.

  • Participate in the development and implementation of hit-finding decision trees (incorporating biochemical, biophysical and cell-based assays) to enable the discovery of new chemical starting points through compound or fragment screening.

  • Independently conceive and execute experimental strategies to enable studies on target biology and compound mechanism of action early in the drug discovery cycle.

  • Represent REVOLUTION Medicines with external organizations.

Required Skills
  • Ph.D. degree in biology, biochemistry or chemical biology with a focus on small molecule, fragment or protein therapeutic discovery (Scientist I).

  • 3+ years Postdoctoral or relevant industry experience (Scientist II) considered but not necessary.

  • Scientific expertise in a number of disciplines including biochemistry, biophysics, enzymology, cell and molecular biology and screening technologies as well as general technical innovation.

  • Rigorous, quantitative and detail-oriented experimentalist with an understanding of statistics.

  • Excellent written and verbal communication skills.

  • Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.

  • Innovative, generous team-player with enthusiasm for our small company environment.