Scientist I/II, Biochemistry and Chemical Biology

REVOLUTION Medicines discovers and develops new drugs that translate frontier cancer targets through exceptional drug discovery delivering revolutionary medicines on behalf of cancer patients. Our innovative science draws inspiration from nature and evolution, which offer insights into cancer targets, disease mechanisms and therapeutic approaches. As a new member of the RevMed team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.


As a member of the Biology Dept and a key player in the Chemical Biology/Biochemistry team, you will:

  • Apply diverse technologies in the laboratory to illuminate the functional roles and mechanisms of action of key proteins in cancer signaling pathways, in particular the RAS pathway.

  • Characterize mechanisms of covalent and non-covalent enzyme inhibitors and small molecule modulators of protein interactions in cells and cell-free systems.

  • Develop cutting edge tools or probes to better understand target biology and guide drug candidate discovery.

  • Collaborate with colleagues in Discovery Technologies and Medicinal Chemistry to provide data-driven guidance to interdisciplinary teams to influence early stage program decisions.

Required Skills
  • Ph.D. in Biochemistry, Chemical Biology, Molecular Biology, or related discipline (Scientist I).

  • 3+ years Postdoctoral or relevant industry experience (Scientist II) considered but not necessary.

  • Strong track record of research productivity with high quality, impactful publications.

  • Practical experience applying diverse biochemical, biophysical and/or chemical biology methods to quantitatively characterize enzyme mechanisms, cellular signaling pathways, or other complex biological processes.

  • Prior expertise in cancer signal transduction pathways, including RAS-MAPK, would be an advantage.

  • Skilled in quantitative data analysis, particularly nonlinear curve fitting and rigorous statistical validation of models.

  • Rigorous, quantitative, and detail-oriented experimentalist with a desire to continue in a laboratory-focused role.

  • Excellent written and verbal communication skills.

  • Demonstrated ability to multi-task, prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.

  • Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high energy, small company environment.