Research: Senior Director, Medicinal Chemistry

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit elusive frontier targets within notorious growth and survival pathways, with particular emphasis on RAS and mTOR signaling pathways. As a new member of the RevMed team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.

Opportunity

As a key member of the Chemistry Leadership Team, you will make significant contributions with accountability for the following:

  • Managing, coaching and mentoring scientists across the discovery function in order to develop their skills and build Revolution Medicines’ organizational capabilities.

  • Playing an instrumental part in the successful delivery of a range of anti-cancer drug candidates for frontier oncology targets.

  • Leading chemistry teams to deliver high-quality chemical equity that advances the early RevMed discovery portfolio: providing research project updates and strategic vision for lead discovery research activities; solving complex scientific challenges when working with novel small molecules;​​​​​​​ potential opportunity to serve as a project leader for drug discovery projects.

  • Being a partner in the scientific activities of other outstanding medical chemists in the department and helping create an environment where we channel scientific curiosity to build and deliver a sustainable portfolio.

  • Advancing the RevMed Research Portfolio and helping build our scientific reputation through presentation/publication of project results in scientific meetings and peer-reviewed literature, as guided by RevMed publication policies, to build our scientific reputation.

  • Demonstrating commitment to the RevMed chemistry department vision to ensure we are acknowledged both internally and externally as a world-class chemistry team focused on frontier cancer targets.

  • Identifying, establishing and leading partnerships with selected CRO partners focused on the design, synthesis and characterization of high-quality compounds.

  • Enhancing our operational efficiency & flexibility through the management of external chemistry CRO resources, continuous improvement activities and implementation of best practice.

  • Actively participating in nominating new frontier cancer targets and establishing new drug discovery programs in the RevMed discovery portfolio.

Required Skills
  • Ph.D. degree in chemistry with over 10 years’ experience in the pharmaceutical/biotech industry alongside a strong track record of scientific innovation in the medicinal chemistry discipline.

  • Demonstrable track record of identifying development candidates against challenging targets with a deep understanding of both hit and lead generation, structure-based drug design and lead optimization.

  • Proven track record of both scientific and people leadership across multi-disciplinary drug discovery teams.

  • Recognized as an intellectual leader in drug discovery with a track record of patents, publications and project achievements.

  • Innovative team-player with high energy for our fast-paced environment.

  • Demonstrated ability to plan and achieve research goals as part of an interdisciplinary team.

  • Experience in leading and managing early discovery projects.

  • Knowledge of oncology therapeutic area and drug discovery.

  • Extensive working knowledge of modern medicinal chemistry and drug discovery techniques.

  • Experience managing scientific collaborations and CRO outsourcing activities.

  • Excellent written and verbal communication skills to work with interdepartmental teams.

  • Evidence of successful coaching, mentorship and development of both individuals and teams in order to build long-term organizational capability.


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