Development: Toxicology Scientist/Preclinical Study Manager, Non-clinical Development and Clinical Pharmacology

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit elusive frontier targets within notorious growth and survival pathways, with particular emphasis on RAS and mTOR signaling pathways. As a new member of the Revolution Medicines team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.

Revolution Medicines is seeking a motivated and energetic individual with a scientific background to be part of the Nonclinical Development and Clinical Pharmacology Organization. This position contributes to and supports the company’s research and development efforts to create new medicines for cancer patients by harnessing the value of frontier oncology targets – proteins that drive the growth of cancers or that control immune responses that can defeat them.

Opportunity

As a key member of our dynamic team, you will have proven expertise in:

  • Designing and technical oversight of in vitro and in vivo preclinical studies conducted at CROS to characterize safety profiles of lead molecules.

  • Working closely with CROs to initiate, monitor and close-out studies in collaboration with internal toxicology, DMPK and bioanalytical team members.

  • Critically reviewing data and study reports, and managing documentation related to internal and outsourced preclinical safety studies.

  • Summarizing and communicating study results to project teams.

  • Managing operational aspects of preclinical studies to ensure timely delivery of key data to inform project decisions.

  • Being a critical contributor to Nonclinical Development and Clinical Pharmacology Organization and multi-disciplinary project teams.

  • Designing and monitoring preclinical safety and toxicology studies to support new chemical entity lead optimization, candidate selection and early development.

  • Broad understanding of preclinical research, including DMPK, safety/toxicology and overall drug discovery.

Required Skills
  • MSc./Ph.D. degree in Life Sciences, Toxicology and Pharmacology, Pharmaceutical Sciences or related fields with  2+ years of Pharm/biotech industry experience, preferrably in oncology small molecule drug discovery and development.

  • Solid technical expertise and operational experience in managing CROs.

  • Thrive in a fast paced biotech environment, capable to manage and prioritize multiple work streams.

  • A collaborative team player with excellent written and verbal communication skills.

  • Knowledge of GLP regulations and conduct of preclinical safety studies a plus.


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