Development: Scientist I/II, DMPK

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit elusive frontier targets in RAS-addicted cancers.  The company’s R&D pipeline includes RMC-4630, a clinical-stage investigational drug that is designed to selectively inhibit the activity of SHP2, an upstream node in RAS signaling. Preclinical programs include inhibitors of multiple mutant RAS proteins and SOS1.  RMC-5552, currently in IND-enabling development, is designed for use against tumors featuring mTORC1 activation, particularly certain RAS-addicted cancers.  As a new member of the Revolution Medicines team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.

Revolution Medicines is seeking a motivated and energetic individual with a scientific background to be part of the Nonclinical Development and Clinical Pharamcology (NDCP) Organization. This position contributes to and supports the company’s research and development efforts to create new medicines for cancer patients by harnessing the value of frontier oncology targets – proteins that drive the growth of cancers or that control immune responses that can defeat them.

Opportunity

As a key member of the NDCP team, you will make significant contributions as follows:

  • Be a key contributor to the NDCP Department and multi-disciplinary research project teams.

  • Design and perform in vitro ADME studies to support lead optimization and candidate selection.

  • Design preclinical PK studies, analyze/interpret data and represent DMPK in project team meetings.

  • Manage CROs in executing out-sourced DMPK studies. 

  • Develop study protocols, maintain detailed documentation of procedures and study records and keep internal database up to date.

  • Author and co-author DMPK study reports, scientific publications, and conference abstracts.    

Required Skills
  • Ph.D. degree in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related fields.

  • Postdoc training (1 – 3 years) in ADME/PK and relevant industry experience are a plus.   

  • Solid skills and hands-on laboratory experience in small molecule bioanalysis using LC-MS/MS.  

  • Experience in designing and conducting ADME/PK studies; proficient in integrating data to drive small molecule drug discovery projects.

  • Strong analytical and problem-solving skills, attention to details.

  • Proficient in data analysis softwares, e.g. Phoenix, GraphPad Prism and ChemDraw.

  • Highly organized with strong record keeping and data management skills.

  • Keen to maximize efficiency and demonstrated ability to meet project timeline.

  • Excellent written and verbal communication skills.

  • Works well both in a dynamic team environment and independently.   


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