Development: Director, Safety Pharmacology and Toxicology

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit elusive frontier targets within notorious growth and survival pathways, with particular emphasis on RAS and mTOR signaling pathways. As a new member of the RevMed team, you will join other outstanding scientists who are helping lead our efforts in the discovery and development of new medicines for unmet needs in cancer.

Revolution Medicines is seeking a motivated and energetic individual with a scientific background to be part of the Nonclinical Development and Clinical Pharmacology Organization. This position contributes to and supports the company’s research and development efforts to create new medicines for cancer patients by harnessing the value of frontier oncology targets – proteins that drive the growth of cancers or that control immune responses that can defeat them. The ideal candidate will be lead the Company’s integrated safety programs from the discovery and preclinical development stage through IND filing and clinical development.


The ideal candidate will have these specific responsibilities:

  • Oversee and provide leadership of Safety Pharmacology and Toxicology within the Nonclinical Development and Clinical Pharmacology (NDCP) Department.

  • Develop and implements nonclinical safety strategies for small molecule oncology drug discovery and development.

  • Manage external resources to design and execute studies to assess nonclinical safety of small molecules supporting lead optimization, candidate selection and development programs.

  • Serve as the Project Toxicologist, communicate nonclinical safety findings and perspectives to cross-functional teams, and effectively interact with partners and collaborators.

  • Communicate and present toxicology updates and input to the Research and Development leadership and corporate governance.

  • Author and review the toxicology component of regulatory documents and participate in regulatory agency interactions.

  • Responsible for functional resource planning and managing the budget of the non-clinical safety and toxicology studies to support.

Required Skills
  • Ph.D. degree or equivalent in cancer biology, cell biology, immunology or a related discipline, with at least five years of relevant industry experience preferably with experience of non-clinical toxicology with experience in oncology.

  • Demonstrable record of strong leadership and teamwork.

  • Strong track record of research productivity as evidenced by high-quality, impactful publications, preferably in the field of cancer biology or related field.

  • Experience of managing CROs.

  • Extensive hands on experience in relevant laboratory techniques.

  • Rigorous, quantitative and detail-oriented experimentalist.

  • Thrives in a collaborative team setting and is driven by a desire to deploy innovative approaches and technologies in a high energy environment.

  • Excellent written and verbal communication skills.

  • Demonstrated ability to prioritize options, anticipate challenges, and execute on goals as a member of an interdisciplinary team is extremely important.